Shark Tank- Jaws and 23& me

It’s Thanksgiving Day 2019, and I am sitting in bed feeling less than grateful. I should be very thankful that I am not in the same place as last year when my jaw was wired shut through the gums and I was awaiting surgery part 2 in December, but instead I am feeling lonely and sorry for myself

Anne Wojcicki, founder of genetics company 23 and Me, joins Shark Tank this week as a guest shark.

All of the people in my life from a year ago have dumped me and moved on. No one takes my illness seriously and they think that I am just a drug seeking fair weather friend, but I know that the truth is that I’ve been minimizing the severity of my condition for too long

I don’t have a pop and click in my jaw like everyone else seems to think that they have. And as I sit here alone in bed watching shark tank, the story of the entrepreneur who developed 23 and me tells her story. When the human genome project came into play and we had more information at our fingertips about how to prevent disease based on genetic factors, the healthcare industry got nervous. There isn’t money in prevention.

So the idea that individuals could become their own advocates, and start to do scientific research based on the results of their genetic testing was a threat.

The National Institute of Dental and Craniomaxillofacial Research has issued a report about the causes, standard tests, and effective treatment TMJ disorders. The findings are unknown, inconclusive and lack evidence based research. Disorders of the TMJ were informally assigned to the dental profession years ago because the medical profession’s insufficient understanding of occlusion and how the teeth and bite affect the joint

But the truth is that the joint is the most complex in the body and the studies are finding a genetic component to the disease…provided evidence supporting previously-reported associations between TMD and two genes: HTR2A and COMT. Other genes were revealed as potential new genetic risk factors for TMD, including NR3C1, CAMK4, CHRM2, IFRD1, and GRK5. While these findings need to be replicated in independent cohorts, the genes potentially represent important markers of risk for TMD and they identify potential targets for therapeutic intervention.

Genetic Markers for TMD

Familial Inheritance of TMD

Gene Mutations Associated with TMJ

TMJ that isn’t from a trauma has genetic link

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